Parkinson’s disease affects network of brain regions that controls whole-body action

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Most visual neuroimaging experiments require participants to fixate on a point in the center of the screen during stimulus presentation. This is important because large parts of the visual system are retinotopically organized (a distorted retina-reflecting map). If participants freely move their eyes, the same image stimulates different parts of this cortical map. Eye movements can introduce strong confounds: models may end up decoding eye position on the cortical map and not stimulus-related cortical patterns. There is debate about the strict necessity of fixation though. It also reduces natural viewing behavior and may suppress activity in higher-level visual areas. In general, reconstruction on free-viewing datasets should be approached with caution.

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3 Strictly speaking, the slope is continuous everywhere except for the data points themselves. ↑

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